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All rights reserved. Consequently, a more adequate classification system for SGAs—as have been called for in the recent yearsTechnische Universität München (HWP II) (C.R. There are other antipsychotics that derive their atypicality from other receptor mechanisms which we outline below. All analyses were 2-tailed with alpha set to 0.05, except for the heterogeneity test (alpha set to 0.1).The search strategy identified 3761 citations.
Coventional antipsychotics are old drugs, they were researched and invented about like quite a few years ago while the atypical antipsychotics are newer drug to treat the psychosis. Implementing Precision Psychiatry: A Systematic Review of Individualized Prediction Models for Clinical Practice ); EliLilly; SanofiAventis to S.L.We thank the following authors and pharmaceutical companies for providing additional information on their studies: D. Addington, I.

Stefan Leucht has received speaker and/or consultancy honoraria from SanofiAventis, BMS, EliLilly, Essex, GlaxoSmithKline, Janssen/Johnson and Johnson, Lundbeck, and Pfizer. He lives in Bristol, surrounded by dogs, elflings and lots of woodland! Therefore, at least for systematic reviews, the use of antiparkinson medication is a useful proxy measure for EPS.The NNT/NNH for the main outcome ranged from 3 to 6 for clozapine but were higher for the other SGAs: for olanzapine and quetiapine, they ranged from 14 to 25. Search for other works by this author on: In an earlier meta-analysis comparing the SGAs with placebo, none of the SGAs induced significantly more EPS than placebo—however, risperidone was almost significant—showing that the EPS risks from the SGAs are generally low but not that there are differences in the amount of EPS among the SGAs.Our analysis also supports the notion that the outcome use of antiparkinson medication at least once is a useful proxy variable for the emergence of EPS. “Inducing EPS or not” therefore is not a good classification basis for atypical antipsychotics. Quality of reporting of meta-analysesBias in meta-analysis detected by a simple, graphical testThe effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: combined results of the North American trialsHow effective are second-generation antipsychotic drugs? UNCONVENTIONAL OR ATYPICAL OR SECOND GENERATION ANTIPSYCHOTICS. No misinformation. Conflict of interest: Christine Rummel-Kluge has received speaker honoraria or travel grants to attend scientific meetings from Janssen-Cilag, EliLilly, and Pfizer. Improves my knowledge and insight into MH medication.Do you have a suggestion for a paper?
No bias.

FKZ: 01KG 0606, GZ: GFKG01100506 to S.L. Novel antipsychotics, extrapyramidal side effects and tardive dyskinesiaThe prevalence of acute extrapyramidal signs and symptoms in patients treated with clozapine, risperidone, and conventional antipsychoticsAkathisia: an updated review focusing on second-generation antipsychoticsSecond-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysisA meta-analysis of head-to-head comparisons of second-generation antipsychotics in the treatment of schizophreniaCochrane Schizophrenia Group in the Cochrane Library ChichesterCochrane Handbook for Systematic Reviews of Interventions 4.2.5, in The Cochrane LibraryAmisulpride versus other atypical antipsychotics for schizophreniaOlanzapine versus other atypical antipsychotics for schizophreniaQuetiapine versus other atypical antipsychotics for schizophreniaRisperidone versus other atypical antipsychotics for schizophrenia (protocol)Zotepine versus other atypical antipsychotics for schizophreniaSertindole versus other atypical antipsychotics for schizophreniaZotepine versus other atypical antipsychotics for schizophreniaAripiprazole versus other atypical antipsychotics for schizophreniaWorld Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophreniaImproving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Search for other works by this author on: Some studies had other risks of bias such as baseline imbalance between groups (also see Excluding studies with risperidone mean daily doses over 6 mg displayed that the results of the primary outcome remained the same in comparison to aripiprazole (no significant difference: Excluding studies with olanzapine mean daily doses over 20 mg showed that the results remained the same for the comparisons of olanzapine and clozapine (no significant difference: Excluding studies with mean daily risperidone doses lower than 4 mg showed that the results remained the same for the comparisons of olanzapine and risperidone (significant difference: The test for funnel plot asymmetry was used only for the comparison of olanzapine vs risperidone because the test is considered reasonable only if 10 or more studies are available.We present the first meta-analysis comparing EPS of SGAs head-to-head. contributed to designing the study, data extraction, statistical analysis, and writing the report.
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