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2011 Mar;13(3):295-6. doi: 10.1093/europace/eur029.Conti A, Del Taglia B, Mariannini Y, Pepe G, Vanni S, Grifoni S, Abbate R, Michelucci A, Padeletti L, Gensini GF.Am J Emerg Med. 2020 Jun 26;2020:1835181. doi: 10.1155/2020/1835181. doi: 10.1016/j.clinthera.2018.01.015. eCollection 2020.Curr Anesthesiol Rep. 2019 Jun;9(2):174-193. doi: 10.1007/s40140-019-00321-4. You should not take MULTAQ if you are in AFib and your doctor is not planning to change you back into normal rhythm. That’s why people with afib, their caregivers, and their doctors and other health care providers need to keep up with the latest research.Doctors and patients need to consider questions such as:The opening salvo from those concerned about Multaq came in an April 2010 article, Of interest is that one of the co-authors, Dr. Kaul, actually voted in favor of Multaq as a member of the FDA Advisory Committee that recommended that the FDA should approve it.Let's look at the three primary issues the JACC article raised: safety, efficacy and when to try Multaq.In pointing to pooled data from six dronedarone trials, Dr. Singh said, "These data suggest that dronedarone has modest antiarrhythmic efficacy (effectiveness)," and that it is only half as effective as amiodarone.

2011 Mar;13(3):295-6. doi: 10.1093/europace/eur029.Gillis AM, Verma A, Talajic M, Nattel S, Dorian P; CCS Atrial Fibrillation Guidelines Committee.Can J Cardiol. In their commentary in the same April 2010 issue of the Singh argued that “treatment with antiarrhythmic drugs should generally be considered only when symptoms persist despite adequate rate control” and that “the available data support only limited use of dronedarone for select patient populations, mostly as a But Torp-Pedersen countered that comparing dronedarone with flecainide, sotalol, or other drugs on the market, as Singh and his coauthors did, “is futile because there are no comparable trials, and comparison with historical data is often misleading.”Another rebuttal to the Singh article was published in the They noted that “The findings of the ATHENA trial are unique in antiarrhythmic drug therapy” and “for the first time, an antiarrhythmic drug has been shown to have an important impact on cardiovascular outcomes.”Now, they concluded, doctors don’t have to settle for simply suppressing afib; they have a promising way to improve patient outcomes via antiarrhythmic therapy.The final word comes from the three afib guidelines committees, none of whom seemed to have agreed with Singh that dronedarone should be second- or third-line treatment for afib. Silverchair Information Systems

doi: 10.1002/14651858.CD005049.pub5.J Atr Fibrillation. Do not take MULTAQ if you have a type of atrial fibrillation (AFib) called permanent AFib. Sotalol and possibly amiodarone increased mortality. - Page 3 eCollection 2019 Apr.Joung B, Lee JM, Lee KH, Kim TH, Choi EK, Lim WH, Kang KW, Shim J, Lim HE, Park J, Lee SR, Lee YS, Kim JB; KHRS Atrial Fibrillation Guideline Working Group.Korean Circ J. The review concluded that all the included antiarrhythmic drugs were efficacious in delaying recurrence of atrial fibrillation. Epub 2010 Mar 25.Wu C, Tcherny-Lessenot S, Dai W, Wang Y, Kechemir H, Gandhi S, Lin S, Juhaeri J.Clin Ther. Notably, Multaq doesn't require hospitalization in order to start patients on the drug, as many of the others do. 2010 Oct;28(8):903-10. doi: 10.1016/j.ajem.2009.05.005. Risks and risk factors. Unable to load your delegates due to an error Europace. Amiodarone, sotalol, procainamide dofetilide, quinidine, ibutilide, flecainide, and propafenone are the other useful medicinal products used to treat atrial fibrillation or cardiac arrhythmia.

2018 Dec;48(12):1033-1080. doi: 10.4070/kcj.2018.0339. No information currently available. People with permanent AFib who take MULTAQ have a higher risk of death, stroke, and needing to be treated in a hospital for heart failure. Patients rated Tikosyn 3.5/5 over Multaq 3.2/5 in overall satisfaction.

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