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Priapism, if not treated promptly, can result in irreversible damage to the erectile tissue. Patients should contact their health care provider or report to the emergency room if they experience signs or symptoms of serotonin syndrome Advise patients and their caregivers to observe for signs of activation of mania/hypomania and instruct them to report such symptoms to the healthcare provider Trazodone hydrochloride tablets with aspirin, NSAIDs, other antiplatelet drugs, warfarin, or other anticoagulants because the combined use of drugs that interfere with serotonin reuptake and these medications has been associated with an increased risk of bleeding. This includes medicines you buy without a prescription, including herbal medicines.

Do not chew or crush Trazodone hydrochloride tablets.

WHAT YOU NEED TO KNOW BEFORE YOU TAKE TRAZODONE CAPSULESDo not take trazodone if any of the above applies to you. Talk to your healthcare provider about the risk to your unborn baby if you take Trazodone hydrochloride tablets.If you become pregnant during treatment with Trazodone hydrochloride tablets, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants. It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression.Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain.You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.Some young people have thoughts about suicide when first taking an antidepressant. Prior to initiating treatment with Trazodone hydrochloride tablets, screen patients for any personal or family history of bipolar disorder, mania, or hypomania Adverse reactions after discontinuation of serotonergic antidepressants, particularly after abrupt discontinuation, include: nausea, sweating, dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), tremor, anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures.

Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.Tell your doctor about all your current medicines. Severe Interactions. If concomitant use of Trazodone hydrochloride tablets with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms.Table 2: Common Adverse Reactions Occurring in ≥ 2% of Trazodone Hydrochloride Tablets-treated Patients and Greater than the Rate of Placebo- Treated Patients as Observed in Controlled Clinical StudiesGeneral disorders and administration site conditions:Table 3: Clinically Important Drug Interactions with Trazodone Hydrochloride Tablets[see Contraindications (4), Dosage and Administration ( Disease-associated maternal and/or embryofetal riskAdvise patients and caregivers to look for the emergence of suicidality, especially early during treatment and when the dosage is adjusted up or down and instruct them to report such symptoms to the healthcare provider Advise patients that Trazodone hydrochloride tablets should be taken shortly after a meal or light snack.

Consider using a lower starting dose in elderly patients.The tricyclic-related antidepressant drugs may be associated with a lower risk of cardiotoxicity in overdosage.Tricyclic and related antidepressants cause dry mouth, coma of varying degree, hypotension, hypothermia, hyperreflexia, extensor plantar responses, convulsions, respiratory failure, cardiac conduction defects, and arrhythmias.

Call your doctor for medical advice about side effects. Talk to your healthcare provider about the best way to feed your baby if you take Trazodone hydrochloride.have taken a Monoamine Oxidase Inhibitor (MAOI) or if you have stopped taking an MAOI in the last 2 weeks.Especially tell your healthcare provider if you take:medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, or antipsychoticsover-the-counter supplements such as tryptophan or St. John’s WortTake Trazodone hydrochloride tablets exactly as your healthcare provider tells you.Trazodone hydrochloride tablets should be taken shortly after a meal or light snack.If you feel drowsy after taking Trazodone hydrochloride tablets, talk to your healthcare provider. Continue typing to refine. Relief of symptoms in all types of depression including depression accompanied by anxiety. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure:To report SUSPECTED ADVERSE REACTIONS contact AvKARE at 1-855-361-3993; email drugsafety@avkare.com; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.The concomitant use of MAOIs and serotonergic drugs including Trazodone hydrochloride tablets increases the risk of serotonin syndrome.Trazodone hydrochloride tablets are contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromineThe concomitant use of serotonergic drugs including Trazodone hydrochloride tablets and other serotonergic drugs increases the risk of serotonin syndrome.Monitor patients for signs and symptoms of serotonin syndrome, particularly during Trazodone hydrochloride tablets initiation.
Your doctor may occasionally change your dose.It may take up to 2 weeks before your symptoms improve. Initially 150 mg daily in divided doses, dose to be taken after food, alternatively initially 150 mg once daily, dose to be taken at bedtime, increased if necessary to 300 mg daily; increased if necessary to 600 mg daily in divided doses, higher dose for use in hospital patients only. Trazodone is an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Discontinue treatment with Trazodone hydrochloride tablets and any concomitant serotonergic agents immediately if the above symptoms occur, and initiate supportive symptomatic treatment. Find out full list of APIs/Orals on indivirtus, a clinical contract research organization in Chandigarh and delhi india.
Prescribing Limits Adults Major Depressive Disorder Outpatients Oral Maximum 400 mg daily. Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults. For Adult. Trazodone hydrochloride 50 mg and 100 mg Capsules, Hard Trazodone hydrochloride • Keep this leaflet. If you are to take your dose as a single dose it should be taken just before going to bed.

We comply with the HONcode standard for trustworthy health information - No reports involved the administration of methylene blue by other routes (such as oral tablets or local tissue injection).
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