The primary role of these agents in clinical practice is for the management of hypertriglyceridemia. doctor or pharmacist) as soon as possible about taking these two medicines together.
2005;5(6):379-87. doi: 10.2165/00129784-200505060-00005.Am J Cardiol.
In conclusion, the extent of gemfibrozil–repaglinide interaction depends on SLCO1B1 genotype. Triglycerides may be reduced by as much as 74 % in some patients.
Gemfibrozil increases the risk of rhabdomyolysis when given with atorvastatin. Clipboard, Search History, and several other advanced features are temporarily unavailable. Atorvastatin (Less Than or Equal To 20 mg)/Gemfibrozil Interactions. However, despite these concerns, there are situations in which the use of gemfibrozil in combination with a statin may be necessary.
Understanding the metabolism of gemfibrozil and the degree of interaction with the various statins will assist health-care providers to optimize safety when this combination is clinically indicated. Springer To be included in the study patients had to fulfill the following criteria: men and women with type 2 diabetes, aged 35–75 yr, no treatment known to interfere with lipid metabolism (nonselective β-blockers, high dose diuretics, systemic steroids, lipid-lowering drugs) in the month preceding inc… Manufacturer advises avoid. Name must be less than 100 characters This interaction may be worse if you currently have any type of kidney problem. Learn about drug interactions between atorvastatin oral and gemfibrozil oral and use the RxList drug interaction checker to check drug combinations. doi: 10.1016/s0002-9149(99)00270-2. Compare Atorvastatin vs Gemfibrozil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Gemfibrozil is a lipid-modifying agent that belongs to the fibric acid derivative class. Understanding the metabolism of gemfibrozil and the degree of interaction with the various statins will assist health-care providers to optimize safety when this combination is clinically indicated.
Atorvastatin raises plasma repaglinide concentrations, probably by inhibiting organic anion transporting polypeptide 1B1 (OATP1B1). Springer Please enable it to take advantage of the complete set of features! 1999 May 13;83(9B):30F-35F.
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Severe. While the use of gemfibrozil has decreased over the years for a variety of reasons, muscle-associated adverse effects is the predominant reason and the one that is most clinically relevant. This information is generalized and not intended as specific medical advice. Clinical Pharmacology & Therapeutics (2008); 84, 4, 488–496 doi: 10.1038/clpt.2008.74
Based on the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults and the National Lipid Association, pharmacologic therapy to reduce triglycerides should be considered when triglyceride levels are ≥500 mg/dL. Atorvastatin rated 4.4/10 vs Gemfibrozil rated 6.1/10 in overall patient satisfaction. Gemfibrozil increases the risk of rhabdomyolysis when given with atorvastatin. Fibric acid derivatives activate peroxisome proliferator activated receptor α (PPAR-α). 2003;3(3):169-78. doi: 10.2165/00129784-200303030-00003.Am J Cardiovasc Drugs.
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