Subjects were administered dextromethorphan (two 20 mg doses given 4 hours apart) with or without linezolid. Minimal to moderate optic nerve degeneration was evident in 2 of 3 male rats after 6 months of dosing, but the direct relationship to drug was equivocal because of the acute nature of the finding and its asymmetrical distribution. Approximately 30% of a linezolid dose is removed during 3 hours of haemodialysis, but no data are available for the removal of linezolid by peritoneal dialysis or haemoperfusion. Podiatry Today is a trademark of HMP. However, these effects did not reverse in juvenile animals treated with linezolid for nearly the entire period of sexual maturation.
All patients should be advised to report symptoms of visual impairment, such as changes in visual acuity, changes in colour vision, blurred vision, or visual field defect. However, there are limited clinical data and it is recommended that linezolid should be used in such patients only when the anticipated benefit is considered to outweigh the theoretical risk (see sections 4.4 and 5.2).The recommended linezolid dosage should be administered orally twice daily.The film-coated tablets may be taken with or without food.Hypersensitivity to linezolid or to any of the excipients listed in section 6.1.Linezolid should not be used in patients taking any medicinal product which inhibits monoamine oxidases A or B (e.g. The primary metabolites of linezolid are removed to some extent by haemodialysis, but the concentrations of these metabolites are still very considerably higher following dialysis than those observed in patients with normal renal function or mild to moderate renal insufficiency.Therefore, linezolid should be used with special caution in patients with severe renal insufficiency who are undergoing dialysis and only when the anticipated benefit is considered to outweigh the theoretical risk.To date, there is no experience of linezolid administration to patients undergoing continuous ambulatory peritoneal dialysis (CAPD) or alternative treatments for renal failure (other than haemodialysis). The ratio of linezolid in saliva and sweat relative to plasma was 1.2:1.0 and 0.55:1.0, respectively. Epub 2003 Jun 25.Ann Pharmacother. Linezolid has mild interactions with at least 23 different drugs. This suggests that it is only necessary to avoid ingesting excessive amounts of food and beverages with a high tyramine content (e.g. It allows continued monitoring of the benefit/risk balance of the medicinal product. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Most patients reported to the FDA with serotonin syndrome were taking SSRIs or serotonin norepinephrine reuptake inhibitors (SNRIs). However, the following information may prove useful: Supportive care is advised together with maintenance of glomerular filtration. Therefore, linezolid is not recommended for use in these circumstances unless close observation and monitoring of the recipient is possible (see sections 4.3 and 4.5).Patients should be advised against consuming large amounts of tyramine-rich foods (see section 4.5).The effects of linezolid therapy on normal flora have not been evaluated in clinical trials.The use of antibiotics may occasionally result in an overgrowth of non-susceptible organisms. Expert panelists review the causes, diagnostic work-up, management, and emerging therapies inherent in the evolving paradigm of irritable bowel syndrome.John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmDThe antibacterial agent linezolid is a nonselective inhibitor of monoamine oxidase (MAO), and when it is combined with serotonergic agents, it has been associated with serotonin syndrome.
The hydroxyethyl glycine metabolite (PNU-142586) is the predominant human metabolite and is believed to be formed by a non-enzymatic process.