2011 Aug 8;171(15):1363-9. doi: 10.1001/archinternmed.2011.330.J Br Menopause Soc. Soybeans are a rich source of isoflavones, a class of phytoestrogens found predominantly in legumes and beans. Name must be less than 100 characters Elsevier Science eCollection 2019. Epidemiological studies suggest a protective effect of soy protein on breast tissue as evidenced by the lower rates of breast cancer in East Asian countries where soy is a predominant part of the diet. Epub 2014 Jun 4.Contemp Clin Trials. Since the current drug therapies available have multiple side effects, including increased risk of developing certain types of cancer or complications, a search for potential nonpharmacologic alternative therapies for osteoporosis is of prime interest. Epub 2010 May 7.Chang KL, Hu YC, Hsieh BS, Cheng HL, Hsu HW, Huang LW, Su SJ.Nutrition. Unable to load your delegates due to an error Name must be less than 100 characters 2013 Jan;29(1):250-7. doi: 10.1016/j.nut.2012.03.009. Evidence from laboratory studies reveals neither a positive nor a negative effect of soy isoflavones on cognition. In addition to providing menopause relief, isoflavones are said to prevent some types of cancer and protect the heart. Epub 2011 Sep 29.Taku K, Melby MK, Kurzer MS, Mizuno S, Watanabe S, Ishimi Y.Bone. eCollection 2020.Kwiecień A, Ruda-Kucerova J, Kamiński K, Babinska Z, Popiołek I, Szczubiałka K, Nowakowska M, Walczak M.Pharmaceutics. 2020 Jan 21;6:189. doi: 10.3389/fnut.2019.00189.
Current data are insufficient to draw definitive conclusions regarding the use of isoflavones as an alternative to estrogen for hormone replacement in postmenopausal women. These ingredients contain very high levels of phytoestrogens, hormones derived from plant origins, that can help cancel out the adverse effects of sharply fluctuating hormones In October 1999, the US Food and Drug Administration authorized the use on food labels of health claims associated with soy protein and the reduced risk of coronary heart disease. Sample A -Effects of soy isoflavones in menopause symptoms . Please enable it to take advantage of the complete set of features! COVID-19 is an emerging, rapidly evolving situation. 2018 Nov 19;23(11):3019. doi: 10.3390/molecules23113019.Remely M, Lovrecic L, de la Garza AL, Migliore L, Peterlin B, Milagro FI, Martinez AJ, Haslberger AG.Br J Pharmacol.
2013 Jun 13;1514:123-7. doi: 10.1016/j.brainres.2013.02.013. However, taking melatonin in combination with soy isoflavones might help psychological symptoms associated with menopause. Epub 2013 Feb 13. This can be very scary if one's period stopped months or even years before. Unable to load your collection due to an error 2013 Dec;14(14):1632-41. doi: 10.2174/1389450114666131216222612.Int J Mol Sci. Actions at the cellular level depend on the target tissue, receptor status of the tissue, and the level of endogenous estrogen.
Data available from human studies on the effect of isoflavones on osteoporosis are limited, and additional studies are needed to support a role in osteoporosis prevention. However, the soy isoflavones do not increase high-density lipoprotein cholesterol or triglyceride levels. Unable to load your delegates due to an error Studies of soy-based diets evaluating the relation between soy consumption and serum lipid concentrations revealed that soy consumption significantly decreased total cholesterol, LDL cholesterol, and triglyceride levels. Osteoporosis is an age-related disorder that affects both women and men, although estrogen deficiency induced by menopause accelerates bone loss in older women. In the Sections A and C of the questionnaire, the women reported their anagraphical data, general health conditions with particular attention to assumption of other drugs, particularly levothyroxine, pre- or -menopausal state and perceived symptoms. Song WO, Chun OK, Hwang I, Shin HS, Kim BG, Kim KS, Lee SY, Shin D, Lee SG.J Med Food. The effects of soy protein on other target tissues reflect estrogenlike agonist and antagonist effects.
Other studies have also illustrated that bone site-specific trophic and synergistic effects combined with exercise intervention might contribute to improve the bioavailability of SI or strengthen the bone-specific effects. COVID-19 is an emerging, rapidly evolving situation. In conclusion, soy isoflavones are biologically active compounds. Although epidemiological and basic laboratory studies allude to the possible protective effects of soy isoflavones at specific target tissues, randomized, placebo-controlled clinical trials are necessary to address these important issues.
Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling. A few studies reveal a minimal effect of soy on hot flashes, with soy reducing hot flashes 45% and placebo causing a 30% reduction compared with an approximate 70% reduction in hot flashes with estrogen replacement therapy.
Several studies have shown that soy protein supplementation (containing isoflavones) reduces both the total and low density (LDL) cholesterol in animal and human studies. 2014 Jul;100 Suppl 1:423S-30S. 2020 Jul 11;21(14):4909. doi: 10.3390/ijms21144909.Nutrients.