Urief(silodosin): Bladder outlet obstruction associated w/ BPH in patients ≥50 yr.
Silodosin falls under a category of drugs known as alpha blockers. The dosage taken can then be adjusted until the patient finds the drug works effectively for them without causing severe side-effects. 24 Jun 2020 Despite this the differences between silodosin and placebo were small. The trials controlled for this by only randomising patients who had not responded during a placebo run-in phase. Ganglionic blockade in the sympathetic ganglia accounts for their effective lowering of blood pressure, particularly in hypertensive patients. The manufacturer states that use of silodosin is contraindicated in patients with severe hepatic impairment (Child-Pugh class C). Our information hub has important information for everyone.Find out more about COVID-19 and the virus that causes it. Health professionals also need to stay up to date with the latest evidence as it emerges. It functions by relaxing the prostate and bladder muscles allowing greater urine flow.
If these symptoms are sufficiently bothersome as to require treatment, selective alpha-blockers such as alfuzosin and tamsulosin are one option.
Silodosin is also a substrate of P-glycoprotein so using it with strong inhibitors (amiodarone, verapamil) of this transporter is not recommended.
However, another review looked at the effectiveness of the following: alpha-blockers, antiinflammatories, antibiotics, finasteride, phytotherapy, gabapentin, glycosaminoglycans, and placebo.Alpha-adrenergic blockers relax the smooth muscle in the prostatic urethra and bladder neck.Doxazosin and terazosin must be titrated up from a starting dose of 1 mg, usually taken at bedtime, to 8 mg maximum for doxazosin and 10 mg maximum for terazosin.