Some of these cases had neither pre-existing liver disease nor a serious underlying medical condition.
PubMed 15. de Mattos.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. If there is no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 100-mg increments to a maximum of 400 mg daily. This includes prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc. 2018 Oct;7(10):629-637. doi: 10.1002/psp4.12338. Epub 2011 Sep 19.Clin Microbiol Rev. Congestive Heart Failure, Cardiac Effects and Drug Interactions. There is limited information regarding cross-hypersensitivity between Itraconazole and other azole antifungal agents. Also tell your doctor if you have or have ever had a heart attack; an irregular heartbeat; or any other type of heart, lung , liver or kidney disease. Treatment of Onychomycosis Toenails with or without fingernail involvement: The recommended dose is 200 mg (2 capsules) once daily for 12 consecutive weeks. 2006 Oct;19(4):763-87. doi: 10.1128/CMR.00059-05.Clin Pharmacokinet. Itraconazole may harm an unborn baby. Itraconazole is excreted mainly as inactive metabolites in urine (35%) and in feces (54%) within one week of an oral solution dose. Itraconazole capsules USP contain 100 mg of Itraconazole, USP coated on sugar spheres (composed of maize starch and sucrose). Itraconazole should be used for the treatment of systemic fungal infections in pregnancy only if the benefit outweighs the potential risk.Itraconazole should not be administered for the treatment of onychomycosis to pregnant patients or to women contemplating pregnancy.

None of the patients who achieved overall success relapsed.Itraconazole is contraindicated for patients who have shown hypersensitivity to Itraconazole. The induced defects included reduced bone plate activity, thinning of the zona compacta of the large bones, and increased bone fragility. Roques S(1), Lytrivi M, Rusu D, Devriendt J, De Bels D. Author information: (1)Intensive Care Department, Brugmann University Hospital, Brussels, Belgium. Unable to load your collection due to an error

The exact cause of the sudden death of the fourth patient was uncertain but we suspected major cardiac arrhythmia was the culprit. As a result, drug pharmacokinetics are altered in patients with renal failure and it is essential to establish guidelines on how to handle this drug in those patients. A pharmacokinetic study using a single 200-mg oral dose of itraconazole was conducted in three groups of patients with renal impairment (uremia: n=7; hemodialysis: n=7; and continuous ambulatory peritoneal dialysis: n=5). The absorption of Itraconazole may be decreased with the concomitant administration of antacids or gastric acid secretion suppressors. We present the case of an 82-year-old man admitted to our hospital for muscle weakness. The protein binding of itraconazole showed no significant changes in patients with chronic renal failure when compared to healthy volunteers (96.64 +/- 0.99% vs. 96.85 +/- 0.33%).

Itraconazole is in a class of antifungals called triazoles. Concentrations in lung, kidney, liver, bone, stomach, spleen and muscle were found to be two to three times higher than corresponding concentrations in plasma, and the uptake into keratinous tissues, skin in particular, up to four times higher. This includes infections in any part of the body including the lungs, mouth or throat, toenails, or fingernails.Itraconazole may also be used for purposes not listed in this medication guide.You should not take itraconazole if you have ever had Stop using itraconazole and call your doctor at once if you have Life-threatening side effects may occur if you take itraconazole with certain other drugs.