94-0603)277. 32nd ed. Sildenafil citrate and blood-pressure-lowering drugs: Results of drug interaction studies with an organic nitrate and a calcium antagonist. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. 246. 300. Yancy CW, Jessup M, Bozkurt B et al. From the 4nRx Web Site (http://www.4nrx.com).271. 289. Gonzalez ER, Jones HD, Graham S et al. Wisznia KI, Lazar M, Leopold IH. Overall cardiovascular profile of sildenafil citrate. Chasseaud LF, Darragh A, Doyle E et al. 248. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. Isosorbide mononitrate is a nitrate-class drug used for the prevention of angina pectoris. Prakash A, Markham A. Long-acting isosorbide mononitrate.
From the Drugquest Web Site (http://www.drugquest.com/doorway.htm) [no longer available online].269. 701. administration, isosorbide-5-mononitrate is distributed into total body water in about 9 minutes with a volume of distribution of approximately 0.6 - 0.7 L/kg. 249. 233. Geneva Generics. Pharmacology. Rutherford JD. 524. Ischemic heart disease: anginal syndromes. Isosorbide dinitrate and isosorbide mononitrate: Organic nitrates; vasodilating agents.Isosorbide dinitrate or mononitrate is used for the acute relief of angina pectoris, for prophylactic management in situations likely to provoke angina attacks, and for long-term prophylactic management of angina pectoris.Conventional measures in the management of angina pectoris are aimed at reducing the frequency, duration, and severity of attacks, and include coronary risk reduction (e.g., discontinuance of smoking, weight control, antilipemic strategies), rest, avoidance of precipitating circumstances (e.g., eating heavy meals, getting emotionally upset, performing strenuous exercise, exposure to cold air) and, if possible, treatment of the underlying cause.β-Adrenergic blocking agents (β-blockers) generally are considered among the initial antianginal drugs of choice in the long-term prophylactic management of chronic stable angina with or without prior MI to reduce symptoms and to prevent MI and/or death.Isosorbide dinitrate or mononitrate can be used alone or in combination as either second-line or third-line therapy in patients previously treated with a β-blocker.Prolonged use of oral nitrates has been associated with the development of tolerance to the hemodynamic and antianginal effects and possibly with cross-tolerance to sublingual nitrates. 256. How to buy almost any drug without a prescription: 1000 Mexican pharmacy contacts - 450 Caribbean pharmacies. Becker RC, Corroa JM, Bovill EG et al. Comparison of the initial hemodynamic effects of immediate-release versus sustained-release isosorbide-5-mononitrate following single oral doses. Clinical mechanisms of nitrate action. Brown BG, Bolson E, Peterson RB et al. Col J, Col-Debeys C, Lavenne-Pardonge E et al. b. AHFS drug information 2004. Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of randomized trials. 264. Deerfield, IL; 1995 Jun.238. (AHCPR publication no. Abrupt withdrawarl of the drug is not recommended because of the possibility of severe exacerbation of anginal symptoms, although no clearcut rebound phenomena were seen. Peczon JD, Grant WM, Lambert BW. 308. Montvale, NJ: Medical Economics Company Inc; 2000:2271-2.322. Flaherty JT. Luscher TF. 284. Isosorbide dinitrate and isosorbide mononitrate. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Key Pharmaceuticals, Kenilworth, NJ. Whitworth CG, Grant WM. ACC/AHA guidelines for the early management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Subcommittee to Develop Guidelines for the Early Management of Patients with Acute Myocardial Infarction). Gruppo Italiano per lo Studio della Sopravvivenza nell’infarto Miocardico. Anon. Robertson D, Stevens RM. 243. )* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) nameOnly references cited for selected revisions after 1984 are available electronically.20. Nyberg G, Blychert LO, Jonsson UE. Uses. Johnson KW, ed. In: Hansten PD, Horn JR. Drug interactions & updates. Kinlay S, Wall RC, Page JH et al. Kloner RA, Zusman RM.
Fung HL. 260. Anon. Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. Sreebny LM, Valdini A. Xerostomia: a neglected symptom. 54th ed. In general, these symptoms disappear during long-term treatment.Other reactions that have been reported with isosorbide mononitrate-modified release tablets include It is sold in the US by Lannett Company, under the trade name β adrenergic receptor antagonists were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias.
234. Marik PE, Varon J. Hypertensive crises: challenges and management. 202. 259. Agency for Health Care Policy and Research. Fung HL, Chung SJ, Bauer JA et al. Use of nitrate and nitrite vasodilators by glaucomatous patients. 280. Bode V, Welzel D, Franz G et al. 263. 286. Bogaert MG. Clinical pharmacokinetics of organic nitrates. American Society of Health-System Pharmacists; 2004:1679-84.PDH. Anon. (See Tolerance and Dependence under Cautions. 221. Yusuf S, Collins R, McMahon S et al.