There are no reports concerning an overdose of aciclovir cream.No untoward effects would be expected if the entire contents of a 20g tube of the cream were ingested. As a result, these patients no longer respond to treatment with aciclovir. After penetration into cells which are infected with herpes simplex virus types I and II (HSV I & HSV II) or varicella-zoster virus (VZV), aciclovir is converted into a virostatic agent. This site uses cookies. This is also confirmed by histologic studies and autopsy. However strains with changed/different virus thymidine kinase or DNA polymerase were also reported. The in vitro studies used human skin biopsates, whilst the bioassays either used human skin grafts on mice or were carried out in the human eye (3 patients). The tubes consisting of aluminium are closed with a polyethylene cap. The tubes are packed individually into cardboard boxes together with package leaflets.42-46 Booth Drive, Park Farm South, Wellingborough, Northamptonshire, NN8 6GTTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Common side effects of Zovirax Cream include: application site reactions such as dry lips, skin sloughing, skin dryness, cracked lips, burning skin, These levels would potentially expose breast fed infants to aciclovir doses of up to 0.3mg/kg/day.Frequency: very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1,000, <1/100); rare ≥1/10,000, <1/1,000), very rare (<1/10,000).• Immediate hypersensitivity reactions including angioedema and urticaria• Transient burning or stinging following application of aciclovir cream• Contact dermatitis following application. Therefore, the following data is based on the data after oral or intravenous administrationPlasma protein binding is reported to range between 9 and 33% as a function of dose. Doses of 800mg five times daily (4 g per day), have been administered without adverse effects. Aciclovir tablets have been shown to have no definite effect upon sperm count, morphology or motility in man.Following oral administration of 200 mg aciclovir five times a day, aciclovir has been detected in breast milk at concentrations ranging from 0.6 to 4.1 times the corresponding plasma levels. Generic Zovirax cream 5% 5gm. When suggestions are available use up and down arrows to review and ENTER to select. AIDS patients or recipients of bone marrow transplants) oral dosing should be considered. 88 ($206.29/Ounce) $34.99 $34.99. You can take Acyclovir with some meals or without, yet constantly in the same means. Redaktor medyczny: John P. Cunha, DO, FACOEP. This information is intended for use by health professionalsThe treatment of Herpes Simplex virus infections of the lips and face (Herpes labialis). However the accidental, repeated overdose of oral aciclovir, over several days has resulted in gastrointestinal effects (nausea and vomiting) and neurological effects (headache and confusion).Aciclovir is dialysable.Aciclovir is a pharmacologically inactive substance. According to the test carried out by Draize, who evaluated the allergic sensitising potential of a substance there were no pathologic findings.Studies carried out in swine showed that 5% aciclovir cream in a PEG vehicle caused an only minimal (quantitative) delay in epidermal wound healing.Rabbits had 1, 3 or 6% aciclovir cream in a white petroleum vehicle introduced directly into both eyes 5 times daily at 90-minute intervals for 3 weeks. 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