However, the extent to which these metabolites contribute to the effects of selegiline are unknown.Many of the prominent symptoms of Parkinson’s disease are due to a deficiency of striatal dopamine that is the consequence of a progressive degeneration and loss of a population of dopaminergic neurons which originate in the substantia nigra of the midbrain and project to the basal ganglia or striatum. Although rare, a few reports of hypertensive reactions have occurred in patients receiving ELDEPRYL at the recommended dose, with tyramine-containing foods.
Mylan manufactures ELDEPRYL®* (selegiline hydrochloride) capsules (Eldepryl) in strengths of 5 mg
-Keep this leaflet. Whether or not it might be effective as a sole treatment is unknown, but past attempts to treat Parkinson’s disease with non-selective MAOI monotherapy are reported to have been unsuccessful. xref In humans, intestinal MAO is predominantly type A, while most of that in brain is type B.In CNS neurons, MAO plays an important role in the catabolism of catecholamines (dopamine, norepinephrine and epinephrine) and serotonin. Thus, after several years of levodopa treatment, the response, for a given dose of levodopa, is shorter, has less predictable onset and offset (i.e., there is ‘wearing off’), and is often accompanied by side effects (e.g., dyskinesia, akinesias, on-off phenomena, freezing, etc. Whether or not this mechanism or an alternative one actually accounts for the observed beneficial effects of adjunctive selegiline is unknown.Selegiline’s benefit in Parkinson’s disease has only been documented as an adjunct to levodopa/carbidopa. 0000001278 00000 n
0000000736 00000 n PACKAGE LEAFLET: INFORMATION FOR THE USER Eldepryl 5 mg Tablets Eldepryl 10 mg Tablets (Selegiline hydrochloride) Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Its chemical name is (R)-methyl (-methylphenylethyl) prop-2-ynlamine hydrochloride.
Educational materials to help empower your customers. Early in the course of Parkinson’s Disease, the deficit in the capacity of these neurons to synthesize dopamine can be overcome by administration of exogenous levodopa, usually given in combination with a peripheral decarboxylase inhibitor (carbidopa).With the passage of time, due to the progression of the disease and/or the effect of sustained treatment, the efficacy and quality of the therapeutic response to levodopa diminishes.
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Eldepryl can cause hypertensive crisis, which is a life-threatening increase in blood pressure. MAOs are also important in the catabolism of various exogenous amines found in a variety of foods and drugs.
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Thus, after several years of levodopa treatment, the response, for a given dose of levodopa, is shorter, has less predictable onset and offset (i.e., there is ‘wearing off’), and is often accompanied by side effects (e.g., dyskinesia, akinesias, on-off phenomena, freezing, etc. Only N-desmethylselegiline has MAO-B inhibiting activity. Serotonin syndrome has also been reported with 3 Reference ID: 3514471 . AZILECT is contraindicated for use with meperidine, tramadol, … Eldepryl are available in a bottle of 100 tablets. Eldepryl. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Eldepryl (selegiline) Skip to: full site navigation. ELDEPRYL ® (selegiline hydrochloride) is a levorotatory acetylenic derivative of phenethylamine.
For the same reason, it is not possible to predict the rate of recovery of MAO-B activity as a function of plasma levels. 0000004970 00000 n
MAOs are currently subclassified into two types, A and B, which differ in their substrate specificity and tissue distribution. ELDEPRYL (selegiline hydrochloride) is a laevorotatory acetylenic derivative of phenethylamine. 31 22 Effects resulting from selegiline administration may also be mediated through its metabolites. 0000007118 00000 n It is also known as L-deprenyl.
Each white, shield-shaped, unscored tablet, debossed on one side with “S” and “5” on the other side. — they are taken up by adrenergic neurons and displace norepinephrine from storage sites within membrane bound vesicles.
What to expect from . Remedy Health Media, LLC does not, by publication of the advertisements contained herein, express endorsement or verify the accuracy and effectiveness of … 0000002911 00000 n
The maximum concentrations of amphetamine and methamphetamine, however, are far below those ordinarily expected to produce clinically important effects.Single oral dose studies do not predict multiple dose kinetics, however, at steady state the peak plasma level of selegiline is 4 fold that obtained following a single dose. As noted above, there is some evidence that it may increase dopaminergic activity by other mechanisms, including interfering with dopamine re-uptake at the synapse. The chemical name is: (R)-(-)-N,2-dimethyl-N-2-propynylphenethylamine hydrochloride. Two of its three principal metabolites, amphetamine and methamphetamine, have pharmacological actions of their own; they interfere with neuronal uptake and enhance release of several neurotransmitters (e.g., norepinephrine, dopamine, serotonin). concomitant use of AZILECT with meperidine, tramadol, methadone, or propoxyphene. Selegiline inhibits MAO by acting as a ‘suicide’ substrate for the enzyme; that is, it is converted by MAO to an active moiety which combines irreversibly with the active site and/or the enzymes essential FAD cofactor.
This site is provided for educational and informational purposes only, in accordance with our In short, attention to the dose dependent nature of selegiline’s selectivity is critical if it is to be used without elaborate restrictions being placed on diet and concomitant drug use although, as noted above, a few cases of hypertensive reactions have been reported at the recommended dose. 0000001017 00000 n