Use of this website is conditional upon your acceptance of our User Agreement.© 2020 Remedy Health Media, LLC ALL RIGHTS RESERVED DEPAKOTE comes in different dosage forms. Your healthcare provider will probably increase your dose slowly until your seizures are controlled or until you experience bothersome side effects.

I have taken depakote and it was wonderful for me!

Diseases & Conditions

Your doctor may occasionally change your dose.Drink plenty of water while you are taking this medication. Do not take two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Drinking alcohol may increase certain side effects of divalproex.Avoid driving or hazardous activity until you know how this medicine will affect you. and formulary information changes. Aa. eMedTV serves only as an informational resource. This website also contains material copyrighted by 3rd parties. In order for us to best serve you and provide you with the best information, can you please tell us if you currently have health insurance? “have been taking Depakote 1500 mg for 2 years, find it calms me down, when anxiety is overwhelming.

Controlled studies in pregnant women show no evidence of fetal risk.May increase levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in brain; may enhance or mimic action of GABA at postsynaptic receptor sites; may also inhibit sodium and calcium channelsDivalproex sodium is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxideEquivalent oral doses of Depakote (divalproex sodium) products and Depakene (valproic acid) capsules deliver equivalent quantities of valproate ion systemically, although the rate of valproate ion absorption may vary with the formulation administered (liquid, solid, or sprinkle), conditions of use (eg, fasting or postprandial) and the method of administrationThese differences should be of minor clinical importancePeak plasma time: 4 hr (tablet); 3.3 hr (sprinkles); 4-17 hr (ER tablet)Protein bound: Concentration dependent; free fraction increases from ~10% at 40 mcg/mL to 18.5% at 130 mcg/mLProtein binding reduced in the elders, chronic hepatic diseases, renal impairment, or with drug that cause displacement (aspirin)CSF: Approximate unbound concentration in plasma (~10% of total concentration) Vd: 11 L/1.73 m2 (total valproate); 92 L/1.73 m2 (free valproate)Divalproex sodium dissociates to the valproate ion in the GI tractValproate metabolized in liver by glucuronidation (30-50%) and mitochondrial beta-oxidation (40%) <15-20% is eliminated by other oxidative mechanismsTotal body clearance: 0.56 L/hr/1.73 m2 (total valproate); 4.6 L/hr/1.73 m2 (free valproate)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.
depakote-divalproex-sodium-999832 2001 I keep taking regular dose and don't play around dosage… DEPAKOTE ® (divalproex sodium) delayed-release tablets, for oral use, and DEPAKOTE ® ER (divalproex sodium) extended-release tablets, for oral use, are prescription medications used: Always consult your doctor about your medical conditions. I was having terrible anxiety and terrible headaches that wouldn't go away. Stopping suddenly may cause a serious, life-threatening type of seizure.You should not use Depakote if you are allergic to divalproex sodium, or if you have:a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.To make sure this medicine is safe for you, tell your doctor if you have:liver problems caused by a genetic mitochondrial disorder;depression, mental illness, or suicidal thoughts or actions; ora family history of a urea cycle disorder or infant deaths with unknown cause.Some people have thoughts about suicide while taking Depakote. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. If you log out, you will be required to enter your username and password the next time you visit. There is no body of evidence available from controlled trials to guide a clinician in the longer term management of a patient who improves during Depakote treatment of an acute manic episode. I am on Topamax for potential seizures and it did not control my anxiety. Comment from: 65-71on Treatment for 6 months to - 1 year Published: April 12.