Get the latest breaking news delivered straight to your inbox.Copyright © 2020 CBS Interactive Inc. All rights reserved. You may report side effects to FDA at 1-800-FDA-1088.Low sodium may be more likely to occur in children and older adults.This is not a complete list of side effects and others may occur. These doses of desmopressin acetate represent approximately <1 times (rat) and 38 times (rabbit) the maximum recommended human dose based on body surface area (mg/mBreastfeeding is not expected to result in clinically relevant exposure of the infant to desmopressin following maternal intranasal administration. Select one or more newsletters to continue. Desmospray® 0.1 mg/ml Nasal Spray PL 03194/0024 ; Desmopressin nasal spray out of stock due to recall. Desmopressin nasal (DDAVP ®) is used to control the symptoms of a certain type of diabetes insipidus ('water diabetes'; condition in which the body produces an abnormally large amount of urine).Desmopressinnasal (DDAVP ®) is also used to control excessive thirst and the passage of an abnormally large amount of urine that may occur after a head injury or after certain types of … Desmopressin acetate at up to 10 mcg/kg/day was given to pregnant rabbits by subcutaneous injection from gestation day 6 to 18 during fetal organogenesis without teratogenic effects. Instruct patients about appropriate fluid restriction during DDAVP Nasal Spray treatment Must prime the spray pump prior to the first use. If administered more than once a day, adjust for an adequate diurnal rhythm of urine output.Because administration of desmopressin acetate can been associated with decreased responsiveness with prolonged use, consider increasing the dosage of DDAVP Nasal Spray if patients demonstrate decreased response over a long period of timeWhen switching from the desmopressin acetate injection to DDAVP Nasal Spray, administer 10 times the amount of desmopressin acetate, rounding down to the nearest 10 mcg.When switching from the desmopressin acetate tablets to DDAVP Nasal Spray individual dose titration is required because intranasal desmopressin is approximately 10 to 40 fold more potent than oral (tablet) desmopressin.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. For children aged 3 months to 12 years, the usual dosage range is 0.05 to 0.3 mL daily, either as a single dose or divided into two doses. DDAVP Nasal Spray is available as a 5 mL bottle with spray pump delivering 50 sprays. DDAVP Nasal Spray is contraindicated in patients with estimated CLcr by Cockcroft-Gault equation less than 50 mL/min Signs of desmopressin acetate overdosage may include confusion, drowsiness, continuing headache, problems with passing urine, and rapid weight gain due to fluid retention DDAVP Nasal Spray is a vasopressin analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation.
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