The γ-hydroxy metabolite, 3-(p-chlorophenyl)-4-hydroxybutyric acid, is formed by the deamination of baclofen Because baclofen is partially metabolized in the liver, patients with impaired liver function should be regularly monitored with liver function tests Baclofen is rapidly and extensively eliminated from the body.

Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid agonist specific for GABA-B receptors.It acts at spinal and supraspinal sites, reducing excitatory transmission.

Experten vermuten, dass Baclofen in die Eine besser erprobte Alternative in Schwangerschaft und Stillzeit stellt der Wirkstoff Medikamente mit Baclofen sind verschreibungspflichtig, da die Betreuung von Patienten mit Multipler Sklerose und Spastiken inklusive einer regelmäßigen Therapie-Erfolgskontrolle sehr wichtig ist. Store the oral solution in the refrigerator.It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

It is also important information to carry with you in case of emergencies.URL of this page: use the sharing features on this page, please enable JavaScript. Für eine bessere Verträglichkeit sollte der Wirkstoff zusammen mit einer Mahlzeit eingenommen werden. Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant used for the relief of painful and uncomfortable muscle spasms caused by a variety of conditions. Baclofen acts on the spinal cord nerves and decreases the number and severity of muscle spasms caused by multiple sclerosis or spinal cord conditions. Do not take more or less of it or take it more often than prescribed by your doctor.Use an oral syringe (measuring device) to accurately measure and take your dose of baclofen solution. If you believe you are experiencing an interaction, contact a healthcare provider immediately.

It usually is taken 3 times a day at evenly spaced intervals. Baclofen's pharmacological class is a gamma-aminobutyric acid (GABA) ergic agonist.

In addition, baclofen has central sites of action, shown by its adverse event profile and general CNS depressant properties Baclofen depresses monosynaptic and polysynaptic reflex transmission, by various actions, and possibly including the stimulation of GABAβ-receptors. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Baclofen prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects. This drug is not indicated in the treatment of skeletal muscle spasm caused by rheumatic disorders. Ein bestimmter Botenstoff, die sogenannte Gamma-Aminobuttersäure (GABA), ist der wichtigste hemmende Botenstoff im zentralen Nervensystem (Bei Erkrankungen oder Verletzungen des Nervensystems ist dieses kontrollierte Gleichgewicht gestört und GABA manchmal nicht ausreichend wirksam. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, di… However, you should not flush this medication down the toilet. Its mechanism of action and pharmacological properties are different from the effects of other antispastic agents. CLASSES. Baclofen is a prescription medicine used to treat the symptoms of spasticity from multiple sclerosis, in particularity for the relief of spasms and concomitant pain, clonus, and muscular rigidity. Baclofen is used to treat pain and certain types of spasticity (muscle stiffness and tightness) from multiple sclerosis, spinal cord injuries, or other spinal cord diseases. Baclofen does not cure these problems, but it may allow other … Dies gilt insbesondere dann, wenn eine Medikamente mit Baclofen dürfen nicht angewendet werden, wenn der Behandelte unter Krampfleiden (Baclofen und andere zentral wirksame Substanten (wie Alkohol, Schlafmittel, Mittel gegen Depressionen oder starke Schmerzmittel) können sich gegenseitig in ihren Wirkungen und Nebenwirkungen verstärken.Der Wirkstoff Baclofen kann die Wirkung von Blutdruck-senkenden Mitteln verstärken, weshalb eine Dosisanpassung notwendig sein kann.Da Baclofen das Reaktionsvermögen beeinträchtigen kann, sollte insbesondere bei Therapiebeginn auf eine aktive Teilnahme am Straßenverkehr und das Bedienen von schweren Maschinen verzichtet werden. Auch in Aceton und in Diethylether ist es praktisch unlöslich. Baclofen also possesses anti-inflammatory properties that may be of interest in the study of addiction treatment The exact mechanism of action of baclofen is not fully understood at this time Baclofen is an effective and widely used antispastic agent with a spinal site of action. Baclofen is not a narcotic.

Common side effects include sleepiness, weakness, and dizziness. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Das bedeutet, dass man die Dosis über einen Zeitraum von etwa zwei bis drei Wochen schrittweise reduzieren muss.Vor allem zu Beginn der Behandlung kann Baclofen Nebenwirkungen wie Magen-Darm-Probleme, Gelegentlich, das heißt bei weniger als einem Prozent der Behandelten, kann es unter anderem zu Der Wirkstoff sollte nur mit Vorsicht angewendet werden, wenn der Patient unter Nierenfunktionsstörungen, schweren psychischen Erkrankungen oder akuten Verwirrungszuständen leidet. Find patient medical information for baclofen oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Baclofen's chemical name is 4-amino- 3-(4- chlorophenyl) butanoic acid, and its structural formula is: Baclofen. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.