RALES was terminated early because of significant mortality benefit demonstrated during a planned interim analysis. When added to standard therapy, spironolactone at a starting dose of … Die Anwendung von Aldactone 25 kann zu Nebenwirkungen & Wechselwirkungen mit anderen Medikamenten oder Wirkstoffen führen. Available for Android and iOS devices. Monitoring of potassium, sodium and other electrolytes levels is necessary.This medicine is not recommended in patients with the kidney disease. Aldactone 25Mg Tablet is available as a 25 mg, 50 mg and 100 mg tablet. This risk is increased by impaired renal function or concomitant potassium supplementation, potassium-containing salt substitutes or drugs that increase potassium, such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers Monitor serum potassium within 1 week of initiation or titration of Aldactone and regularly thereafter. Aldactone is used to treat heart failure, high bl...MS - General Surgery, MBBS Bachelor of Medicine and Bachelor of Surgery In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2%–4% and 15%–20%, respectively.Pregnant women with congestive heart failure are at increased risk for preterm birth. Consult Online With India's Top Doctors See detailed T&CHow long does it take for this medicine to take effect?The effect of this medicine can be observed in 2 to 4 hours.The effect of this medicine lasts for an average duration of 2 to 3 days.Is it safe to consume alcohol while taking this medicine?Consumption of alcohol is not recommended while you are taking this medicine. Version: 11.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Uses of Aldactone 25 mg Tablet: Aldactone 25 mg Tablet can help in treatment of high blood pressure and edema (fluid overload) related to heart, liver, kidney and/or lung diseases by getting rid of any surplus fluid and repairing symptoms like breathing problems. But heart patients need a word of caution , these medicines are diuretics , means produce more urine to get rid of extra water in the body, with the result there is more p...MBBS, MD - Internal Medicine, DM - Cardiology, Fellowship in EP

The active constituent of this medication is an antagonist that acts via binding of the receptors at the site of potassium exchange within distal renal tubules. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Ask your doctor about any risk.Take Aldactone exactly as prescribed by your doctor. Hyperkalemia may occur, especially in patients with impaired renal function.Aldactone oral tablets contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, 17-hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone acetate, which has the following structural formula:Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform.Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, and titanium dioxide.Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. There are no data on spironolactone effects on milk production. Your doctor may occasionally change your dose.Do not share this medicine with another person, even if they have the same symptoms you have.You may take Aldactone with or without food, but take it the same way each time.This medicine can affect the results of certain medical tests. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for Tell your doctor about all your other medicines, especially:heart or blood pressure medicine (especially another diuretic);This list is not complete. In these patients, initiate Aldactone in the hospital Clearance of spironolactone and its metabolites is reduced in patients with cirrhosis. Patients who were tolerant of one tablet daily at 8 weeks may have had their dose increased to 50 mg daily at the discretion of the investigator. Consider the developmental and health benefits of breastfeeding along with the mother's clinical need for spironolactone and any potential adverse effects on the breastfed child from spironolactone or from the underlying maternal condition.Safety and effectiveness in pediatric patients have not been established.Aldactone is substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Toxnet.nlm.nih.gov.