It does not work fast enough to relieve the pain of an angina attack that has already started.Isosorbide dinitrate belongs to the group of medicines called nitrates. It should be inspected before use and discarded if either color or particulate is observed.Promethazine hydrochloride is a phenothiazine derivative which possesses antihistaminic, sedative, antimotion-sickness, antiemetic, and anticholinergic effects. 1. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Promethazine hydrochloride (10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl-, monohydrochloride, (±)-) is a racemic compound and has the following structural formula:Each mL contains promethazine hydrochloride, either 25 mg or 50 mg, edetate disodium 0.1 mg, calcium chloride 0.04 mg, sodium metabisulfite 0.25 mg and phenol 5 mg in Water for Injection. The product is light sensitive. If phenergan rectal fails, reliable space, a rate should be made whether to take nursing or to aid the drug, information for causing sneezing.
When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
Structural differences from the neuroleptic phenothiazines result in its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Promethazine is a competitive H1 receptor antagonist, but does not block the release of histamine. Make sure you tell your doctor if you have any other medical problems, especially:This form of nitrate is used to reduce the number of angina attacks over a long time. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.)
Getting up slowly may help.Dizziness, lightheadedness, or fainting is also more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. For example, 5-hydroxytryptamine type 3 (5-HT3) recep-tor antagonists may be used for both pro-phylaxis and as a rescue antiemetic. Local Pharmacy and Therapeutics (P&T) Committees must determine instances where use of promethazine HCl injection is absolutely necessary. WARNINGS Respiratory Depression – Pediatrics Promethazine hydrochloride injection should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. pH 4.0 to 5.5; buffered with acetic acid-sodium acetate.Promethazine hydrochloride injection is a clear, colorless solution.
These headaches are a sign that the medicine is working.
It will not relieve an attack that has already started because it works too slowly. It is best to inject this medication deep into a muscle. For this medicine, the following should be considered:Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. The Isordil brand name has been discontinued in the U.S. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.
Do Dizziness, lightheadedness, or faintness may occur, especially when you get up quickly from a lying or sitting position.
The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated.
Available for Android and iOS devices. Due to the close proximity of arteries and veins in the areas most commonly used for intravenous injection, extreme care should be exercised to avoid perivascular extravasation or unintentional intra-arterial injection as pain, severe chemical irritation, severe spasm of distal vessels, and resultant gangrene requiring amputation are likely under such circumstances.
Local facilities must review their current practices regarding administration of promethazine HCl injection.
encephalopathy or Reye's syndrome.
BOXED WARNING. Do not double doses.Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Although not all of these side effects may occur, if they do occur they may need medical attention.Other side effects not listed may also occur in some patients.
See DOSAGE AND ADMINISTRATION for important notes on administration.WARNINGS - Severe Tissue Injury, Including GangrenePromethazine hydrochloride injection should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. Avoid concomitant administration of other drugs with respiratory depressant effects because of an association with respiratory depression, and sometimes death, in pediatric patients.damage to tissues regardless of the route of administration.Because of the risks of intravenous injection, the preferred route of administration of promethazine hydrochloride injection is deep intramuscular injection (see DOSAGE AND ADMINISTRATION). For non-prescription products, read the label or package ingredients carefully.Appropriate studies have not been performed on the relationship of age to the effects of isosorbide dinitrate in the pediatric population. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.If you miss a dose of this medicine, take it as soon as possible.