Therefore, hydroxyzine may be a good fit for those with anxiety disorders and comorbid insomnia.Most present-day anxiolytics act as serotonin reuptake inhibitors or modulate the function of GABA (gamma-aminobutyric-acid). Blockade of D2 receptors is known to prevent hyperdopaminergic reactions such as anxiety, paranoia, and agitation. One hypothesis is that H1 receptor inhibition As most individuals are aware, increasing serotonin in certain regions can reduce anxiety – perhaps this is one mechanism by which hydroxyzine is anxiolytic. Participants were set to receive either hydroxyzine 50 mg per day or a placebo for a period of 4 weeks.Severity of participant anxiety was measured with the Hamilton Rating Scale for Anxiety (HAM-A). But the main reason I was taking it was sleeplessness.

Aside from anaphylaxis, this molecule and the raving of the writers of this article, claiming cure-all status, it is useless compared to benzodiazepines.

Panic attacks are common in people with anxiety disorders, although some people don’t experience panic at all. Going for therapy too.I am 62. Although dosages can be lowered to minimize fatigue, anxiolytic relief may be insignificant at lower doses.Although some studies suggest hydroxyzine’s anxiolytic efficacy, particularly among those with generalized anxiety disorders, a review of evidence notes that these studies may have had biases. Authors concluded that hydroxyzine is a therapeutic intervention for generalized anxiety disorder.A study published by Darcis et al. Although some may question the quality and duration of these studies, nearly all results highlight the anxiolytic efficacy of hydroxyzine when compared to a placebo and/or FDA-approved anxiolytics. Your healthcare provider will determine the dose and method of taking the medication that is right for you based upon your response. That said, it may be helpful to read and understand the results of each study for yourself, especially if you are considering hydroxyzine as an anxiolytic intervention.A case study published by Iskandar, Griffeth, and Rubio-Cespedes C. (2011) documented a patient with panic disorder who utilized hydroxyzine to attenuate his panic attack. Side effects were more common in the hydroxyzine group (e.g. Once an individual becomes tolerant to the highest hydroxyzine dose, he/she will have reached a peak and may eventually find that even the highest dose “stops working” (due to tolerance). When I ran out of my benzos (which was all the time) I used 75mg of atarax and would feel almost fine. instead of saying, "Boy, that drug really works well.

Moreover, it is likely that a complex reaction of altered neurotransmission of histamine (at H1 receptors), increased levels of serotonin, and decreased sympathetic activation – contribute to hydroxyzine’s anxiolytic effect.Ironically, a metabolite of hydroxyzine known as norchlorcyclizine of similar chemical structure to trazodone, possibly yielding analogous effects. Vistaril can also be prescribed as an antihistamine to treat allergic reactions. Unfortunately, because of some side effects with Trazodone, I had to stop taking it – but Hydroxyzine honestly feels very similar.Trazodone, in my experience, had a higher sedative effect for helping with sleep- but hydroxyzine’s anxiolytic (anti-anxiety) effect has been greater.

For this reason, those who fail to respond to SSRIs or benzos may want to consider hydroxyzine – it exerts completely different neurochemical effects.Since hydroxyzine exhibits a unique mechanism of action, it may prove efficacious in the attenuation of anxious symptoms among a subset of individuals with refractory cases. When you are practicing the skills of facing your fears, if you notice the effects of a medication, you may tend to attribute your successes more to the medication than to your own efforts.