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Should hyperkalaemia develop Aldactone should be discontinued, and if necessary, active measures taken to reduce the serum potassium to normal (see section 4.3).Reversible hyperchloraemic metabolic acidosis, usually in association with hyperkalaemia has been reported to occur in some patients with decompensated hepatic cirrhosis, even in the presence of normal renal function.Concomitant use of Aldactone with other potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs, angiotensin II antagonists, aldosterone blockers, heparin, low molecular weight heparin or other drugs or conditions known to cause hyperkalaemia, potassium supplements, a diet rich in potassium or salt substitutes containing potassium, may lead to severe hyperkalaemia.Reversible increases in blood urea have been reported in association with Aldactone therapy, particularly in the presence of impaired renal function. Nachdem ich das hier gelesen habe ist es aber vollkommen okay für mich.Zur Behandlung meines hohen Blutdrucks, verbunden mit Wasser in den Beinen, verschrieb mir der Arzt Candesartan und Hygroton. There was also a statistically significant, but not dose-related, increase in benign uterine endometrial stromal polyps in females.In a 12-month study dietary study in rats with potassium canrenoate (a compound chemically similar to spironolactone and whose primary metabolite, canrenone, is also a major product of spironolactone in man) a dose-related (above 30 mg/kg/day) incidence of myelocytic leukaemia was observed for a period of 1 year. Continue typing to refine. All patients were taking a loop diuretic, 97% were taking an ACE inhibitor and 78% were on digoxin (at the time this trial was conducted, b-blockers were not widely used to treat heart failure and only 15% were treated with a b-blocker). Unverträglichkeiten besser zuordnen zu können, sollte ich erst einmal nur Hygroton nehmen. Pharmacokinetic studies have been performed on the individual component of spironolactone and hydroflumethiazide.Following oral administration of 500 mg tritiated spironolactone in five healthy male volunteers (fasting state), the total radioactivity in plasma reached a peak between 25 and 40 minutes. ich habe bis vor einigen Tagen HCT 25 viele Jahre eingenommen und jetzt wurde bei mir ein stark reduzierter natriumwert im Krankenhaus festgestellt. Aldactone belongs to a group of medicines called ‘diuretics’ – you may know these as ‘water’ tablets. Aldactide should not be administered with other potassium conserving diuretics and potassium supplements should not be given routinely with Aldactide as hyperkalaemia may be induced. Hydroflumethiazide is excreted in human milk in small amounts. • concomitant use of eplerenone or other potassium sparing diuretics.Spironolactone is contraindicated in paediatric patients with moderate to severe renal impairment.Aldactone should not be administered concurrently with other potassium conserving diuretics and potassium supplements should not be given routinely with Aldactone as hyperkalaemia may be induced.Fluid and electrolyte status should be regularly monitored particularly in the elderly, in those with significant renal and hepatic impairment.Hyperkalaemia may occur in patients with impaired renal function or excessive potassium intake and can cause cardiac irregularities which may be fatal. With spironolactone, feminisation has been observed in male rat foetuses.HCTZ did not cause reproductive toxicity when administered to pregnant mice or rats.Hydroflumethiazide does cross the placental barrier. In the presence of metabolic activation, spironolactone and canrenoate have been found to be mutagenic, inconclusive or negative in mammalian tests in vitro. Caution should be exercised in the management of patients subjected to regional or general anaesthesia while they are being treated with Aldactide.The absorption of a number of drugs including thiazides is decreased when co-administered with cholestyramine and colestipol.Concurrent use of lithium and thiazides may reduce lithium clearance leading to intoxication.Since ACE inhibitors decrease aldosterone production they should not routinely be used with Aldactide, particularly in patients with marked renal impairment.Non-steroidal anti-inflammatory drugs such as aspirin, indometacin, and mefanamic acid may attenuate the natriuretic efficacy of diuretics due to inhibition of intrarenal synthesis of prostaglandins and have been shown to attenuate the diuretic effect of spironolactone.In fluorimetric assays, spironolactone may interfere with the estimation of compounds with similar fluorescence characteristics.Spironolactone enhances the metabolism of antipyrine. There are theoretical concerns with use in CAs, which may be mitigated by risk minimisation. Ich hatte ständig Schwächeanfälle und mein Blutdruck war erneut stark erhöht. Nach oben. !Besonders die Ausführungen zu Chlortalidon. dosierungsfrage bezüglich aldactone.